Initial Therapeutics discovers and develops new small molecule treatments focused on known, rationally selected targets that play key roles in cancer and other serious illnesses. Initial interdicts high-value protein targets with its STOPS (selective termination of protein synthesis) platform. Selectively modulating translation of pathogenic proteins in the exit tunnel of the ribosome, when the proteins are in their linear sequence stage and before they are fully formed, makes possible a new kind of therapeutic with the potential to stop disease processes in their initial, earliest stages. Located in South San Francisco, Initial Therapeutics was founded by life sciences venture capital firm Apple Tree Partners and a team of prominent, veteran biotechnology entrepreneurs who have pioneered advances in ribosome biochemistry, proteomics, medicinal chemistry, DNA-encoded library technology, and chemical genetics. Initial's proprietary platform brings together technologies from its founders into uniquely enabling combinations of expertise and capabilities.

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